About: MTOR inhibitors

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Class of pharmaceutical drugs

Property	Value
dbo:description	class of pharmaceutical drugs (en) skupina léků, které inhibují jeden typ savčí serin/threoninové kinázy (cs)
dbo:thumbnail	wiki-commons:Special:FilePath/Sirolimus3d.png?width=300
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dbr:Interstitial_lung_disease dbr:Polyene dbr:Streptomyces_hygroscopicus dbr:Long-term_potentiation dbr:Oceania dbr:Oxygen dbr:C-terminus dbr:Candida_albicans dbr:G1_phase dbr:Macrolide dbr:Methylation dbr:Hydrophile dbr:T_cell dbr:Cell_signaling dbr:Protein_biosynthesis dbr:Chemotherapy dbr:RICTOR dbr:Bcl-2-associated_death_promoter dbr:Chromosome_10 dbr:Combination_therapy dbr:Autophosphorylation dbc:Antineoplastic_drugs dbr:Protein dbr:Astrocytoma dbr:Cytokine dbr:Novartis dbr:Mechanism_of_action dbr:EIF4E dbr:Insulin-like_growth_factor dbr:Protein_kinase_domain dbr:Phosphatidylinositol_3-kinase-related_kinase dbr:Easter_Island dbr:Microorganism dbr:Mitochondrion dbr:PH dbr:Adenosine_triphosphate dbr:Cryptococcus_neoformans dbr:European_Medicines_Agency dbr:Breast_cancer dbr:Apoptosis dbr:Bcl-2 dbr:Colony-stimulating_factor dbr:Everolimus dbr:HER2 dbr:PTEN_(gene) dbr:Phosphoinositide_3-kinase dbr:Protein_kinase_B dbr:Sorafenib dbr:Sunitinib dbr:Asparagine dbr:Cell_cycle dbr:Cell_growth dbr:Huntingtin dbr:Ionization dbr:Nausea dbr:Tyrosine dbr:Food_and_Drug_Administration dbr:Loss_of_heterozygosity dbr:Prostate_cancer dbr:Mutation dbr:Aspergillus_fumigatus dbr:Cytoskeleton dbr:National_Cancer_Institute dbr:Eukaryotic_initiation_factor dbr:Stomatitis dbr:Tyrosine_kinase_inhibitor dbr:Restenosis dbr:Umirolimus dbr:Prodrug dbr:Downregulation_and_upregulation dbr:In_vitro dbr:Sarcoma dbr:Neuroendocrine_tumor dbr:Small_molecule dbr:Temsirolimus dbr:P70-S6_Kinase_1 dbr:PI3K/AKT/mTOR_pathway dbr:Alpha_helix dbr:N-terminus dbr:P53 dbr:Vincristine dbr:Glioblastoma dbr:Hydrogen_bond dbr:Atherosclerosis dbr:Feedback dbr:GTPase dbr:Ridaforolimus dbr:Protein_phosphatase_2 dbr:Neratinib dbr:EIF4EBP1 dbr:FKBP1A dbr:FKBP5 dbr:Immunosuppression dbc:Human_proteins dbr:Vascular_endothelial_growth_factor dbr:Autophagy dbr:Protein_kinase dbc:Tor_signaling_pathway dbr:MTOR dbr:Pharmacokinetics dbr:Signal_transduction dbr:Cell_survival_curve dbr:Bcl-xL dbr:Cyclin_D1 dbr:Cyclosporine dbr:Drug_class dbr:Platelet-derived_growth_factor dbr:Phosphine_oxide dbr:Clinical_trials dbr:Antineoplastic dbr:Dactolisib dbr:Interleukin_4 dbr:Coronary_arteries dbr:Enzyme_substrate_(biology) dbr:Catalytic dbr:Dual-specificity_kinase dbr:Rac_(GTPase) dbr:Rho_family_of_GTPases dbr:Upstream_and_downstream_(DNA) dbr:Biologic_medical_product dbr:Mammalian_target_of_rapamycin dbr:Renal_transplantation dbr:Amino_acids dbr:AKT dbr:Preclinical dbr:Tyrosine_kinase dbr:Mutations dbr:Hypoxia-inducible_factors dbr:MAPKAP1 dbr:MLST8 dbr:CDKN1B dbr:KRAS dbr:Coronary dbr:PI3K dbr:Monotherapy dbr:Zotarolimus dbr:Akt/PKB_signaling_pathway dbr:Angiopoietin_1 dbr:Basic_fibroblast_growth_factor dbr:Interleukin_3 dbr:MTORC1 dbr:MTORC2 dbr:PKC_alpha dbr:Paxillin dbr:Sapanisertib dbr:Torin-1 dbr:Voxtalisib dbr:Hydrogen_bonds dbr:Corticosteroids dbr:Organ_rejection dbr:Antifungal_medication dbr:Rapamycin dbr:Neurodegenerative_diseases dbr:EFNB2 dbr:U.S._Food_and_Drug_Administration dbr:Isoforms dbr:Structure-activity_relationship dbr:Neurodegeneration dbr:Growth_factors dbr:PI3K_inhibitor dbr:Amplification_(molecular_biology) dbr:Substrate_(biochemistry) dbr:Transformation_(genetics) dbr:Response_Evaluation_Criteria_in_Solid_Tumors dbr:Hemiketal dbr:Methoxy dbr:Mechanistic_target_of_rapamycin dbr:Serine/threonine_kinase dbr:Multiprotein_complex dbr:Pre-clinical_development dbr:HEAT_repeat_domain dbr:Neuroendocrine_tumors dbr:PIK3CA dbr:Cyclosporine_A dbr:Cytostatic dbr:FKBP12 dbr:Interleukin_1_family dbr:KIAA1303 dbr:HER-2 dbr:Immunosuppressive dbr:Large_B-cell_lymphoma dbr:MRNA_translation dbr:TGF_beta dbr:File:Dactolisib.svg dbr:File:Domain_structure_of_mTOR.png dbr:File:Dual_inhibitors.jpg dbr:File:Effects_of_Rapamycin_and_its_rapalogs_in_cancer_cells.png dbr:File:Effects_of_Rapamycin_and_rapalogs_on_endothelial_and_tumor_cells.png dbr:File:Everolimus.svg dbr:File:FKBP-sirolimus-mTOR_complex_1FAP.png dbr:File:MTOR_complexes.png dbr:File:MTOR_signal_pathway.jpg dbr:File:Ridaforolimus.svg dbr:File:Sapanisertib.svg dbr:File:Sirolimus_and_temsirolimus.svg dbr:File:Sirolimus_binding_sites.svg dbr:Ground_glass_abnormalities dbr:Wikt:_rapalog dbr:S6K1 dbr:Protein_complexes dbr:Upregulation
dbp:alt	Sirolimus ball-and-stick model (en)
dbp:biologicalTarget	mTOR (en) FKBP12 (en)
dbp:caption	Ball-and-stick model of sirolimus, the prototype mTOR inhibitor (en)
dbp:mechanismOfAction	mTOR inhibition (en)
dbp:name	mTOR inhibitors (en)
dbp:use	dbr:Immunosuppression
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dct:subject	dbc:Oncology dbc:Signal_transduction dbc:Cancer_treatments dbc:Antineoplastic_drugs dbc:Human_proteins dbc:Tor_signaling_pathway
gold:hypernym	dbr:Kinase
rdfs:label	MTOR inhibitors (en) مثبطات mTOR (ar) MTOR inhibitory (cs)
owl:sameAs	freebase:MTOR inhibitors yago-res:MTOR inhibitors wikidata:MTOR inhibitors dbpedia-ar:MTOR inhibitors dbpedia-cs:MTOR inhibitors dbpedia-global:MTOR inhibitors dbr:MTOR inhibitors
prov:wasDerivedFrom	wikipedia-en:MTOR_inhibitors?oldid=1292966043&ns=0
foaf:depiction	wiki-commons:Special:FilePath/Ridaforolimus.svg wiki-commons:Special:FilePath/Dactolisib.svg wiki-commons:Special:FilePath/Domain_structure_of_mTOR.png wiki-commons:Special:FilePath/Dual_inhibitors.jpg wiki-commons:Special:FilePath/Effects_of_Rapamycin_and_its_rapalogs_in_cancer_cells.png wiki-commons:Special:FilePath/Effects_of_Rapamycin_...gs_on_endothelial_and_tumor_cells.png wiki-commons:Special:FilePath/FKBP-sirolimus-mTOR_complex_1FAP.png wiki-commons:Special:FilePath/MTOR_signal_pathway.jpg wiki-commons:Special:FilePath/Sapanisertib.svg wiki-commons:Special:FilePath/Sirolimus3d.png wiki-commons:Special:FilePath/Sirolimus_and_temsirolimus.svg wiki-commons:Special:FilePath/Sirolimus_binding_sites.svg wiki-commons:Special:FilePath/MTOR_complexes.png wiki-commons:Special:FilePath/Everolimus.svg
foaf:isPrimaryTopicOf	wikipedia-en:MTOR_inhibitors
is dbo:treatment of	dbr:Cardiac_allograft_vasculopathy
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is dbp:class of	dbr:Ketamine/temsirolimus
is rdfs:seeAlso of	dbr:Sirolimus
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