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- QB Tyrod Taylor and RB LeSean McCoy led an effective run-first offense under Ryan and in Sean McDermott's first year as head coach, both playing a big role in breaking the Bills' playoff drought in 2017 (en)
- Thurman Thomas and Andre Reed were among Kelly's top weapons during the Super Bowl years as part of the "K-Gun" offense, while Bruce Smith was a ferocious pass-rusher on defense. (en)
- Tre'Davious White , Micah Hyde and Jordan Poyer were integral players in Buffalo's defensive secondary during the early McDermott era. (en)
- The "big three" of Chan Gailey's surprisingly efficient offense consisted of former late-round draft picks or undrafted players. From top to bottom: QB Ryan Fitzpatrick, RB Fred Jackson and WR Stevie Johnson (en)
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